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常重 アントニオ
生命科学部 生命機能学科
教授
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https://researchmap.jp/read0147112
経歴
■ 経歴
- 2011年09月 - 現在
非常勤講師 筑波大学 - 2007年04月 - 現在
教授 法政大学 - 2001年07月 - 現在
客員教授 ＵＰＣＨ - 2004年04月 - 2007年03月
准教授 法政大学 - 2002年09月01日 - 2004年03月31日
University of Pennsylvania, School of Medicine Res. Associate Professor - 2002年09月 - 2004年03月
University of Pennsylvania, School of Medicine,Res. Associate Professor - 1992年09月01日 - 2002年08月31日
University of Pennsylvania, School of Medicine Senior Research Associate - 1992年09月 - 2002年08月
University of Pennsylvania, School of Medicine,Senior Research Associate - 1989年07月05日 - 1992年08月31日
University of Pennsylvania, school of Medicine Post-doctoral fellow - 1989年07月 - 1992年08月
University of Pennsylvania, school of Medicine,Post-doctoral fellow
研究活動情報
■ 論文
■ 所属学協会
- ORP-pH関係に基づく台湾の温泉研究
大河内正一・大波英幸・連祥淵・常重アントニオ・揚麗芳・木村和男・中村 徹・甘其銓
温泉科学, 2020年, ［査読有り］ - 光反応による水素化硫黄泉の製造の可能性
温泉科学, 2018年, ［査読有り］ - 水素による髪の紫外線ダメージ制御効果について
大河内 正一、新原 寛晃、山岡 卓司、市田 かなみ、鍵和田 聡、常重アントニオ
温泉科学, 2018年, ［査読有り］ - Tracing whale myoglobin evolution by resurrecting ancient proteins.
Isogai Y; Imamura H; Nakae S; Sumi T; Takahashi KI; Nakagawa T; Tsuneshige A; Shirai T
Sci Rep. 2018 Nov 15;8(1):16883. doi: 10.1038/s41598-018-34984-6., 2018年, ［査読有り］ - Isothermal Titration Calorimetry and Oxygen Binding Studies between Inositol Hexakisphosphate and Human Hemoglobin
A. Tsuneshige; T. Yonetani
Biophysical Journal 114(3):417a, 2018年 - Change of the isoelectric point of hemoglobin at the air/water interface probed by the orientational flip-flop of water molecules.
Devineau S; Inoue KI; Kusaka R; Urashima SH; Nihonyanagi S; Baigl D; Tsuneshige A; Tahara T.
Phys Chem Chem Phys. 2017 Apr 19;19(16):10292-10300. 28383588, 2017年, ［査読有り］ - De Catenanos y Rotaxanos a Interruptores,Sensores y Coches Moleculares
Tsuneshige, A
Acta Herediana 59, 36-41 (2016), 2016年, ［査読有り］, ［招待有り］ - 酸性硫黄泉の特性について
大河内 正一,栗田 繕彰,梅田 一輝,常重アントニオ,
温泉科学, 2015年, ［査読有り］ - T-quaternary structure of oxy human adult hemoglobin in the presence of two allosteric effectors, L35 and IHP
Kenji Kanaori; Yusuke Tajiri; Antonio Tsuneshige; Izumi Ishigami; Takashi Ogura; Kunihiko Tajima; Saburo Neya; Takashi Yonetani
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2011年10月, ［査読有り］ - A New Paramagnetic Intermediate Formed during the Reaction of Nitrite with Deoxyhemoglobin
Maria T. Salgado; Somasundararn Ramasamy; Antonio Tsuneshige; Periakaruppan T. Manoharan; Joseph M. Rifkind
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011年08月 - “T-quaternary structure of oxy human adult hemoglobin in the presence of two allosteric effectors, L35 and IHP.
Kanaori K; Tajiri Y; Tsuneshige A; Ishigami I; Ogura T; Tajima K; Neya S; Yonetani T
Biochim. Biophys. Acta, 2011年, ［査読有り］ - “A new paramagnetic intermediate formed during the reaction of nitrite with deoxyhemoglobin”
Maria T. Salgado; Somasundaram Ramasamy; Antonio Tsuneshige; Periakaruppan; T. Manoharan; Joseph M. Rifkind
J. Am. Chem. Soc., 2011年, ［査読有り］ - ヘテロトロピックなエフェクター存在下におけるオキシヘモグロビンのR-T構造変化(ヘム蛋白質 )
Tajiri Yusuke; Tsuneshige Antonio; Yonetani Takashi; Kanaori Kenji
生物物理, 2011年 - "Method for determination of association and dissociation rate constants of reversible bimolecular reactions by isothermal titration calorimetry"
Tsuyoshi Egawa; Antonio Tsuneshige; Makoto Suematsu; Takashi Yonetani
Analytical Chemistry, 2007年, ［査読有り］ - Method for determination of association and dissociation rate constants of reversible bimolecular reactions by isothermal titration calorimeters.
Egawa T; Tsuneshige A; Suematsu M; Yonetani T.
Anal Chem. 2007 Apr 1;79(7):2972-8, 2007年, ［査読有り］ - Erythrocytes with T-state-stabilized hemoglobin as a therapeutic tool for postischemic liver dysfunction
Kazuhiro Suganuma; Kosuke Tsukada; Misato Kashiba; Antonio Tsuneshige; Toshiharu Furukawa; Tetsuro Kubota; Nobuhito Goda; Masaki Kitajima; Takashi Yonetani; Makoto Suematsu
ANTIOXIDANTS & REDOX SIGNALING, 2006年09月, ［査読有り］ - “R-state Haemoglobin with Low Oxygen Affinity: Crystal Structures of Deoxy Human and Carbonmonoxy Horse Haemoglobin Bound to the Effector Molecule L35”
Yokoyama, T; Neya; S. Tsuneshige, A; Yonetani, T; Park, S-Y; Tame, J.R.H
J. Mol. Biol., 2006年02月, ［査読有り］ - “Allosteric Effectors Influence the Tetramer Stability of Both R- and T-states of Hemoglobin A”
Schay,G; Smeller, L; Tsuneshige, A; Yonetani, T; Fidy、J
J. Biol. Chem., 2006年, ［査読有り］ - “T-state stabilization of hemoglobin allostery by nitric oxide: a protection against post-ischemic hepatobiliary dysfunction”
Suganuma, K; Tsukada, K; Tsuneshige, A; Kashiba, M; Yonetani, T; Suematsu, M
Antioxid. Redox Signaling, 2006年, ［査読有り］ - The Effect of Solvation on the Allosteric Properties of the Bluefin Tuna Hemoglobin
Kenjo Tomotaka; Tsuneshige Antonio; Miyazaki Gentaro; Imai Kiyohiro
生物物理, 2006年 - Allosteric effectors influence the tetramer stability of both R- and T-states of hemoglobin A.
Schay G; Smeller L; Tsuneshige A; Yonetani T; Fidy J.
J Biol Chem. 2006 Sep 8;281(36):25972-83., 2006年, ［査読有り］ - Diverse Effects of Amphipathic-Amphoteric Kosmotropes on the Oxygenation
Haga Takehiko; Tsuneshige Antonio
生物物理, 2005年 - Semihemoglobins, high oxygen affinity dimeric forms of human hemoglobin respond efficiently to allosteric effectors without forming tetramers
A Tsuneshige; K Kanaori; U Samuni; D Danstker; JM Friedman; S Neya; L Giangiacomo; T Yonetani
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004年11月, ［査読有り］ - A novel blood transfusant candidate: Intact human erythrocytes containing hemoglobin exclusively nitrosylated in the alpha-subunits
Tsuneshige; A. & Yonetani; T.
Adv. Exp. Med. Biol., 2003年, ［査読有り］ - Global allostery model of hemoglobin - Modulation of O-2 affinity, cooperativity, and Bohr effect by heterotropic allosteric effectors
T Yonetani; S Park; A Tsuneshige; K Imai; K Kanaori
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002年09月, ［査読有り］ - Description of hemoglobin oxygenation under universal solution conditions by a global allostery model with a single adjustable parameter
K Imai; A Tsuneshige; T Yonetani
BIOPHYSICAL CHEMISTRY, 2002年07月, ［査読有り］ - Heterotropic effectors control the hemoglobin function by interacting with its T and R states - a new view on the principle of allostery
A Tsuneshige; S Park; T Yonetani
BIOPHYSICAL CHEMISTRY, 2002年07月, ［査読有り］ - "Oxygenation properties of human erythrocytes containing exclusively -nitrosyl hemoglobin: A promising blood transfusant candidate"
Tsuneshige, A; Yonetani, T
Artificial Cells, Blood Substitutes, & Immobilization Biotechnology, 2001年, ［査読有り］ - Oxygen binding by alpha(Fe2+)(2)beta(Ni2+)(2) hemoglobin crystals
S Bruno; S Bettati; M Manfredini; A Mozzarelli; M Bolognesi; D Deriu; C Rosano; A Tsuneshige; T Yonetani; ER Henry
PROTEIN SCIENCE, 2000年04月, ［査読有り］ - UV resonance Raman studies of alpha-nitrosyl hemoglobin derivatives: Relation between the alpha 1-beta 2 subunit interface interactions and the Fe-histidine bonding of alpha heme
S Nagatomo; M Nagai; A Tsuneshige; T Yonetani; T Kitagawa
BIOCHEMISTRY, 1999年07月, ［査読有り］ - 2PA107 ヒト正常Hbの部分配位構造 : α(Fe-NO) β(Fe-deoxy)を中心に
長友 重紀; 長井 雅子; Tsuneshige Antonio; 米谷 隆; 北川 禎三
生物物理, 1999年 - Electron paramagnetic resonance and oxygen binding studies of alpha-nitrosyl hemoglobin - A novel oxygen carrier having no-assisted allosteric functions
T Yonetani; A Tsuneshige; YX Zhou; XS Chen
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998年08月, ［査読有り］ - Zinc-substituted hemoglobins: alpha- and beta-chain differences monitored by high-resolution emission spectroscopy
K Sudhakar; M Laberge; A Tsuneshige; JM Vanderkooi
BIOCHEMISTRY, 1998年05月, ［査読有り］ - Oxygen binding by single crystals of hemoglobin: The problem of cooperativity and inequivalence of alpha and beta subunits
S Bettati; A Mozzarelli; GL Rossi; A Tsuneshige; T Yonetani; WA Eaton; ER Henry
PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1996年08月, ［査読有り］ - SPECTROPHOTOMETRIC, ELECTRON-PARAMAGNETIC RESONANCE AND OXYGEN BINDING-STUDIES ON THE HEMOGLOBIN FROM THE MARINE POLYCHAETE PERINEREIS-AIBUHITENSIS (GRUBE) - COMPARATIVE PHYSIOLOGY OF HEMOGLOBIN
A TSUNESHIGE; K IMAI; H HORI; TYUMA, I; T GOTOH
JOURNAL OF BIOCHEMISTRY, 1989年09月 - THE BINDING OF HEMOGLOBIN TO RED-CELL MEMBRANE LOWERS ITS OXYGEN-AFFINITY
A TSUNESHIGE; K IMAI; TYUMA, I
JOURNAL OF BIOCHEMISTRY, 1987年03月
- “Global view of allostery: A predictable allosteric behavior of hemoglobin is dictated by heterotropic effectors.”
in Hemoglobin: Recent Developments and Topics, Nagai, M. editor., 2011年 - “Kosmotropic Salts from the Hofmeister Series Decrease the Oxygen Affinity of Human Hemoglobin A”
Tsuneshige, A; Haga, T
”Fronteras Científicas en el Siglo XXI”, J. Navarro, ed., Editorial Cordillera, SAC, 2007年, ［査読有り］ - The global allostery model of hemoglobin: an allosteric mechanism involving homotropic and heterotropic interactions
T Yonetani; A Tsuneshige
COMPTES RENDUS BIOLOGIES, 2003年06月, ［査読有り］
- Revisiting a Classical Allosteric Protein - Examination of an Obliterated Interface
A. Tsuneshige; S. Unzai
2020年02月17日 - Growth model for Legionella pneumophila in a household bathtub
A. Tsuneshige; N. Kato; A. Ohno; H. Oguma; Y. Knaroji; A. Kishimoto; H. Ohnami; S. Okouchi
2019年11月23日 - Survey on the ORP-pH correlation in Hot Springs in Taiwan
共著
2019年11月23日 - Insight into the two-state allosteric model
A. Tsuneshige; S.Unzai, 共著
Biophysical Society of Japan, 2019年09月24日 - Function of N-Acetylation of fish hemoglobin alpha-subunit
S. Unzai; A. Tsuneshige, 共著
Biophysical Society of Japan, 2019年09月24日 - Feasibility of Hydroge-Containing Sulfur Hot Spring Water Produced by UV Light Irradiation
H. Niihara; A. Tsuneshige; S. Okouchi
Journal of Hot Spring Science, Japan, 68, 2-12, 2018年 - Isothermal Titration Calorimetry and oxygen Biinding Studies Between Inositol Hexakisphosphate and Human Hemoglobin
A. Tsuneshige; T. Yonetani
2018年 - Isothermal Titration Calorimetry and Oxygen Binding Studies between Inosito Hexakisphosphate and Human Hemoglobin
A. Tsuneshige; S. Unzai; T. Yonetani, Biophysical Society Annual Meeting, February 17-21, 2018, Baltimore, Maryland, USA
2018年 - Change of the isoelectric point of hemoglobin at the air/water infterface probed by the orientational flip-flop of water molecules
S. Devineau; K.I. Inoue; R. Kusaka; S.H. Urashima; S. Nihonyanagi; D. Bagi; A. Tsuneshige; T. Tahara, Phys Chem Chem Phys 19 (16) 10292-10300
Phys Chem Chem Phus, 2017年 - 光反応による水素化温泉水の提案（V)
新原寛晃,常重アントニオ,大河内 正一, 日本温泉科学会第70回大会（2017）那須，栃木健
2017年 - 水素水による紙の紫外線ダメージ御製効果（II)
常重アントニオ,山岡 卓司,新原 寛晃,市田 ,鍵和田 聡,大河内 正一, 日本温泉科学会第70回大会（2017）那須，栃木健
日本温泉科学会, 2017年 - Suppression Effect of Oxidative Damage on Hair by Hydrogen Water
2017年 - Suppression Effect of Oxidative Damage of Hair by Hydrogen Water
H. Niihara, T; Yamaoka; K. Ichida; S. Kagiwada; A. Tsuneshige; S. Okouchi, The 7th Meeting of the Japanese Biochemical Society for Molecular Hydroge, Nagoya, Japan
2017年 - Disassembly and Impact on Function of a Multimeric Allosteric Protein by Kosmotropes
A. Tsuneshige; S. Unzai, 日本生物物理学会 第55回年会，2017年9月19日-21日，熊本大学黒髪北地区，熊本市，熊本県
2017年 - From Catenates and Rotaxanes to Molecular Switches, Sensors, and Cars
A. Tsuneshige, Acta Herediana, 59, 36-41
Acta Herediana, 2016年 - Tracing Evolution of Whale Myoglobin by Resurrecting Ancient Proteins
Y. Isogai; H. Imamura; S. Nakae; K. Takahashi; T. Sumi; T. Nakagawa; A. Tsuneshige; T. Shirai, 54th Annual Meeting of the Biophysical Society of Japan, November, 25-27, Tsukuba, Japan
2016年 - Characteristics of Acidic Sulfur Hot Spring Water
S. Okouchi; Y. Kurita; K. Umeda; A. Tsuneshige, J. Hot Spring Sci, 65, 2-13
Japanese Society of Hot Spring Sciences, 2015年
- Alteration of an Obliterated Interface in a Classical Allosteric Protein Causes Unexpected Functional Changes
A. Tsuneshige
66th Biophysical Society Annual Meeting, 2022年02月19日 - Structural Insight into the Double Allosteric Mechanism for the Oxygenation Function in Hemoglobin: Beyond the MWC Model
A. Tsuneshige; S. Unzai
The XXth International Conference on Oxygen Binding and Sensing Proteins (O2PiP), 2018年, ［招待有り］ - Method for Introducing Hydrogen in Bathtub Water
H. Ohnami; A. Tsuneshige; S. Okouchi
The 8th Annual Meeting of the Japanese Society for Medical and Biological Research on Molecular Hydrogen, 2018年 - Tracing Seal Myoglobin Evolution by Resurrecting Ancient Proteins
1.磯貝 泰弘,今村 比呂志,中江 摂,墨 智成,高橋 健一,中川 太郎,常重アントニオ,白井 剛
第19日本蛋白質学会年会・第71回日本細胞生物学大会合同次大会, 2018年 - 海洋哺乳類ミオグロビンの分子進化：自然はどのようにして高溶解度で安定な蛋白質を作り出したか？
2.磯貝 泰弘,今村 比呂志,中江 摂,墨 智成,高橋 健一,中川 太郎,常重アントニオ,白井 剛
第5回富山・バーゼル医薬研究開発シンポジウム, 2018年 - Isothermal Titration Calorimetry and Oxygen Binding Studies between Inositol Hexakisphosphate and Human Hemoglobin
A. Tsuneshige; T. Yonetani
The 62th Annual Meeting of the Biophysical Society, San Francisco, USA, 2018年 - 光反応による水素化温泉水の提案（V）
新原 寛晃,常重アントニオ,大河内 正一
日本温泉科学会第70回大会（2017）9月6日～9日，那須, 2017年 - 水素水による髪の紫外線ダメージ抑制効果（III）
常重アントニオ,山岡卓司,新原 寛晃,市田 叶美,鍵和田 聡,大河内 正一
日本温泉科学会第70回大会（2017）9月6日～9日，名古屋，愛知県．, 2017年 - Suppression Effect of Oxidative Damage of Hair by Hydrogen Water
Niihara, H; Yamaoka, T; Ichida, K; Kagiwada, S; Tsuneshige, A; Okouchi, S
The 7th Meeting of the Japanese Biochemical Society for Molecular Hydrogen, Nagoya, Japan., 2017年 - Interactions Between as Classical Protein and a Strong Effector – Revisited
Sakurai, S; Sawada, D; Yonetani, T; Tsuneshige, A
60th Annual Meeting of the Biophysical Society February 27~March 3, San Francisco, USA., 2016年 - Reconstruction of an Allosteric Protein from Its Components and the Origin of Allosteric Cross-Talk
Tokoro, T; Tsuneshige, A
XIX International Conference in Oxygen Binding, September 12-14, 2016, Hamburg, Germany., 2016年 - Effect of chemical modifications of amino acids as point mutations in protein function
Tsuneshige, A; Sakurai, S
The International Cheical Congress of Pacific Basin Societies, Honolulu, HI. USA, 2015年12月15日 - 酵素による重曹泉の炭酸化について
常重アントニオ,桜井 俊輔,澤田 大貴,中橋 里奈,服部 佑亮,大河内 正一
日本温泉科学会第68回大会，山形県天童温泉, 2015年09月09日 - Antialgae activity of calcinated colemanite
Hikari, S; Sato; A. Ohnami; H. Tsuneshige, A; Okouchi, S
The International Chemical Congress of Pacific Basin Societies, Honolulu, HI, UA, 2015年 - Effects of magnesium hydride as a reductive bath additive for the skin
Kurita, Y; Mukae, Y; Umeda; K. Tsuneshige, A; Okouchi, S
The International Chemical Congress of the Pacific Basin Societies, Honolulu, HI, USA, 2015年 - Sulfur hot spring containing hydrogen generated by UV irradiation
Niihara, H; Mukae, Y; Kurita, Y; Umeda, K; Tsuneshige, A; Okouchi, S
The International Chemical Congress of the Pacific Basin Societies, Honolulu, HI, USA, 2015年 - Effect of hydrogen on plant growth subjected to salinity stress
Yamaoka.nT; Kurita, Y; Okouchi, S; Tsuneshigem A
The International Chemical Congress of the Pacific Basin Societies, Honolulu, HI, USA, 2015年 - Evaluation of freshness of fermented foods by aging index criterion
Hattori, Y; Kuria, Y; Suzuki, T; Okouchi, S; Tsuneshige, A
The International Chemical Congress of the Pacific Basin Societies, Honolulu, HI, USA, 2015年 - Interactions between inositol hexakisphosphate and hemoglobin studied by isothermal titration calorimetry and oxygen binding measurements
Sakurai, S; Sawada, T; Yonetani, T; Tsuneshige, A
The 53rd Annual Meeting of the Biophysical Society of Japan, Kanazawa, Japan, 2015年 - Insight Into the Origin of Allostery. Stepwise Reconstruction Of An Allosteric Protei n From Its Subunits
Tatsunori Tokoro
2014 IUPAB Congress, Brisbane, Australia, 2014年08月03日
■ 所属学協会
