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TSUNESHIGE Antonio
Faculty of Bioscience and Applied Chemistry Department of Frontier Bioscience
Professor
Researchmap URL
https://researchmap.jp/read0147112
Career
■ Career
- Sep. 2011 - Present
Tsukuba University, Dept. of Chemistry - Apr. 2007 - Present
Professor Hosei University - Jul. 2001 - Present
Invited Professor Universidad Peruana Cayetano Heredia - Apr. 2004 - Mar. 2007
Associate Professor - 01 Sep. 2002 - 31 Mar. 2004
University of Pennsylvania, School of Medicine Res. Associate Professor - Sep. 2002 - Mar. 2004
University of Pennsylvania, School of Medicine,Res. Associate Professor - 01 Sep. 1992 - 31 Aug. 2002
University of Pennsylvania, School of Medicine Senior Research Associate - Sep. 1992 - Aug. 2002
University of Pennsylvania, School of Medicine,Senior Research Associate - 05 Jul. 1989 - 31 Aug. 1992
University of Pennsylvania, school of Medicine Post-doctoral fellow - Jul. 1989 - Aug. 1992
University of Pennsylvania, school of Medicine,Post-doctoral fellow
- 01 Apr. 1985 - 30 Jun. 1989, Graduate School, Medical School, Osaka University, Osaka, Japan, Graduate School, Division of Medical Sciences
- Apr. 1985 - Jun. 1989, Graduate School, Medical School, Osaka University, Osaka, Japan, Graduate School, Division of Medical Sciences
- Apr. 1977 - Jul. 1981, Universidad Peruana Cayetano Heredia, Chemistry, Science
Research activity information
■ Paper
■ Affiliated academic society
- Survey on the Relationship between ORP-pH on Hot Springs in Taiwan
大河内正一・大波英幸・連祥淵・常重アントニオ・揚麗芳・木村和男・中村 徹・甘其銓
Journal of Hot Spring Science, 2020, [Reviewed] - Feasibility of Hydrogen-Containing Sulfur Hot Spring Water Produced by UVLight Irradiation
Journal of Hot Spring Science, 2018, [Reviewed] - Hydrogen Inhibits Damaging Effects of UVRadiation on Hair
Okouchi; S; Niihara; H.; Yamaoka; T; Ichida K; Kagiwada; S; Tsuneshige; A
Journal of Hot Spring Science, 2018, [Reviewed] - Tracing whale myoglobin evolution by resurrecting ancient proteins.
Isogai Y; Imamura H; Nakae S; Sumi T; Takahashi KI; Nakagawa T; Tsuneshige A; Shirai T.
Sci Rep. 2018 Nov 15;8(1):16883. doi: 10.1038/s41598-018-34984-6., 2018, [Reviewed] - Isothermal Titration Calorimetry and Oxygen Binding Studies between Inositol Hexakisphosphate and Human Hemoglobin
A. Tsuneshige; T. Yonetani
Biophysical Journal 114(3):417a, 2018 - Change of the isoelectric point of hemoglobin at the air/water interface probed by the orientational flip-flop of water molecules.
Devineau S; Inoue KI; Kusaka R; Urashima SH; Nihonyanagi S; Baigl D; Tsuneshige A; Tahara T.
Phys Chem Chem Phys. 2017 Apr 19;19(16):10292-10300. 28383588, 2017, [Reviewed] - De Catenanos y Rotaxanos a Interruptores,Sensores y Coches Moleculares
Tsuneshige; A.
Acta Herediana 59, 36-41 (2016), 2016, [Reviewed], [Invited] - 酸性硫黄泉の特性について
大河内 正一; 栗田 繕彰; 梅田 一輝; 常重アントニオ
温泉科学, 2015, [Reviewed] - T-quaternary structure of oxy human adult hemoglobin in the presence of two allosteric effectors, L35 and IHP
Kenji Kanaori; Yusuke Tajiri; Antonio Tsuneshige; Izumi Ishigami; Takashi Ogura; Kunihiko Tajima; Saburo Neya; Takashi Yonetani
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Oct. 2011, [Reviewed] - A New Paramagnetic Intermediate Formed during the Reaction of Nitrite with Deoxyhemoglobin
Maria T. Salgado; Somasundararn Ramasamy; Antonio Tsuneshige; Periakaruppan T. Manoharan; Joseph M. Rifkind
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2011 - “T-quaternary structure of oxy human adult hemoglobin in the presence of two allosteric effectors, L35 and IHP.
Kanaori K; Tajiri Y; Tsuneshige A; Ishigami I; Ogura T; Tajima K; Neya S; Yonetani T.
Biochim. Biophys. Acta, 2011, [Reviewed] - A new paramagnetic intermediate formed during the reaction of nitrite with deoxyhemoglobin.
Salgado MT; Ramasamy S; Tsuneshige A; Manoharan PT; Rifkind JM.
J Am Chem Soc., 2011, [Reviewed] - ヘテロトロピックなエフェクター存在下におけるオキシヘモグロビンのR-T構造変化(ヘム蛋白質 )
Tajiri Yusuke; Tsuneshige Antonio; Yonetani Takashi; Kanaori Kenji
生物物理, 2011 - "Method for determination of association and dissociation rate constants of reversible bimolecular reactions by isothermal titration calorimetry"
Tsuyoshi Egawa; Antonio Tsuneshige; Makoto Suematsu; Takashi Yonetani
Analytical Chemistry, 2007, [Reviewed] - Method for determination of association and dissociation rate constants of reversible bimolecular reactions by isothermal titration calorimeters.
Egawa T; Tsuneshige A; Suematsu M; Yonetani T.
Anal Chem. 2007 Apr 1;79(7):2972-8, 2007, [Reviewed] - Erythrocytes with T-state-stabilized hemoglobin as a therapeutic tool for postischemic liver dysfunction
Kazuhiro Suganuma; Kosuke Tsukada; Misato Kashiba; Antonio Tsuneshige; Toshiharu Furukawa; Tetsuro Kubota; Nobuhito Goda; Masaki Kitajima; Takashi Yonetani; Makoto Suematsu
ANTIOXIDANTS & REDOX SIGNALING, Sep. 2006, [Reviewed] - R-state haemoglobin with low oxygen affinity: Crystal structures of deoxy human and carbonmonoxy horse haemoglobin bound to the effector molecule L35
T Yokoyama; S Neya; A Tsuneshige; T Yonetani; SY Park; JRH Tame
JOURNAL OF MOLECULAR BIOLOGY, Feb. 2006, [Reviewed] - “Allosteric Effectors Influence the Tetramer Stability of Both R- and T-states of Hemoglobin A”
Schay; G.; Smeller; L.; Tsuneshige; A.; Yonetani; T. & Fidy、J.
J. Biol. Chem., 2006, [Reviewed] - “T-state stabilization of hemoglobin allostery by nitric oxide: a protection against post-ischemic hepatobiliary dysfunction”
Suganuma; K.; Tsukada; K.; Tsuneshige; A.; Kashiba; M.; Yonetani; T. & Suematsu; M.
Antioxid. Redox Signaling, 2006, [Reviewed] - The Effect of Solvation on the Allosteric Properties of the Bluefin Tuna Hemoglobin
Kenjo Tomotaka; Tsuneshige Antonio; Miyazaki Gentaro; Imai Kiyohiro
生物物理, 2006 - Allosteric effectors influence the tetramer stability of both R- and T-states of hemoglobin A.
Schay G; Smeller L; Tsuneshige A; Yonetani T; Fidy J.
J Biol Chem. 2006 Sep 8;281(36):25972-83., 2006, [Reviewed] - Diverse Effects of Amphipathic-Amphoteric Kosmotropes on the Oxygenation
Haga Takehiko; Tsuneshige Antonio
生物物理, 2005 - Semihemoglobins, high oxygen affinity dimeric forms of human hemoglobin respond efficiently to allosteric effectors without forming tetramers
A Tsuneshige; K Kanaori; U Samuni; D Danstker; JM Friedman; S Neya; L Giangiacomo; T Yonetani
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2004, [Reviewed] - A novel blood transfusant candidate: Intact human erythrocytes containing hemoglobin exclusively nitrosylated in the alpha-subunits
Tsuneshige; A. & Yonetani; T.
Adv. Exp. Med. Biol., 2003, [Reviewed] - Global allostery model of hemoglobin - Modulation of O-2 affinity, cooperativity, and Bohr effect by heterotropic allosteric effectors
T Yonetani; S Park; A Tsuneshige; K Imai; K Kanaori
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2002, [Reviewed] - Description of hemoglobin oxygenation under universal solution conditions by a global allostery model with a single adjustable parameter
K Imai; A Tsuneshige; T Yonetani
BIOPHYSICAL CHEMISTRY, Jul. 2002, [Reviewed] - Heterotropic effectors control the hemoglobin function by interacting with its T and R states - a new view on the principle of allostery
A Tsuneshige; S Park; T Yonetani
BIOPHYSICAL CHEMISTRY, Jul. 2002, [Reviewed] - Oxygenation properties of human erythrocytes containing exclusively alpha-nitrosyl hemoglobin: A promising blood transfusant candidate
A Tsuneshige; T Yonetani
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY, 2001, [Reviewed] - Oxygen binding by alpha(Fe2+)(2)beta(Ni2+)(2) hemoglobin crystals
S Bruno; S Bettati; M Manfredini; A Mozzarelli; M Bolognesi; D Deriu; C Rosano; A Tsuneshige; T Yonetani; ER Henry
PROTEIN SCIENCE, Apr. 2000, [Reviewed] - UV resonance Raman studies of alpha-nitrosyl hemoglobin derivatives: Relation between the alpha 1-beta 2 subunit interface interactions and the Fe-histidine bonding of alpha heme
S Nagatomo; M Nagai; A Tsuneshige; T Yonetani; T Kitagawa
BIOCHEMISTRY, Jul. 1999, [Reviewed] - 2PA107 ヒト正常Hbの部分配位構造 : α(Fe-NO) β(Fe-deoxy)を中心に
長友 重紀; 長井 雅子; Tsuneshige Antonio; 米谷 隆; 北川 禎三
生物物理, 1999 - Electron paramagnetic resonance and oxygen binding studies of alpha-nitrosyl hemoglobin - A novel oxygen carrier having no-assisted allosteric functions
T Yonetani; A Tsuneshige; YX Zhou; XS Chen
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1998, [Reviewed] - Zinc-substituted hemoglobins: alpha- and beta-chain differences monitored by high-resolution emission spectroscopy
K Sudhakar; M Laberge; A Tsuneshige; JM Vanderkooi
BIOCHEMISTRY, May 1998, [Reviewed] - Oxygen binding by single crystals of hemoglobin: The problem of cooperativity and inequivalence of alpha and beta subunits
S Bettati; A Mozzarelli; GL Rossi; A Tsuneshige; T Yonetani; WA Eaton; ER Henry
PROTEINS-STRUCTURE FUNCTION AND GENETICS, Aug. 1996, [Reviewed] - SPECTROPHOTOMETRIC, ELECTRON-PARAMAGNETIC RESONANCE AND OXYGEN BINDING-STUDIES ON THE HEMOGLOBIN FROM THE MARINE POLYCHAETE PERINEREIS-AIBUHITENSIS (GRUBE) - COMPARATIVE PHYSIOLOGY OF HEMOGLOBIN
A TSUNESHIGE; K IMAI; H HORI; TYUMA, I; T GOTOH
JOURNAL OF BIOCHEMISTRY, Sep. 1989 - THE BINDING OF HEMOGLOBIN TO RED-CELL MEMBRANE LOWERS ITS OXYGEN-AFFINITY
A TSUNESHIGE; K IMAI; TYUMA, I
JOURNAL OF BIOCHEMISTRY, Mar. 1987
- “Global view of allostery: A predictable allosteric behavior of hemoglobin is dictated by heterotropic effectors.”
in Hemoglobin: Recent Developments and Topics, Nagai, M. editor., 2011 - “Kosmotropic Salts from the Hofmeister Series Decrease the Oxygen Affinity of Human Hemoglobin A”
Tsuneshige; A. & Haga; T.
”Fronteras Científicas en el Siglo XXI”, J. Navarro, ed., Editorial Cordillera, SAC, 2007, [Reviewed] - The global allostery model of hemoglobin: an allosteric mechanism involving homotropic and heterotropic interactions
T Yonetani; A Tsuneshige
COMPTES RENDUS BIOLOGIES, Jun. 2003, [Reviewed]
- Revisiting a Classical Allosteric Protein - Examination of an Obliterated Interface
A. Tsuneshige; S. Unzai
17 Feb. 2020 - Growth model for Legionella pneumophila in a household bathtub
A. Tsuneshige; N. Kato; A. Ohno; H. Oguma; Y. Knaroji; A. Kishimoto; H. Ohnami; S. Okouchi
23 Nov. 2019 - Survey on the ORP-pH correlation in Hot Springs in Taiwan
Joint work
23 Nov. 2019 - Insight into the two-state allosteric model
A. Tsuneshige; S.Unzai, Joint work
Biophysical Society of Japan, 24 Sep. 2019 - Function of N-Acetylation of fish hemoglobin alpha-subunit
S. Unzai; A. Tsuneshige, Joint work
Biophysical Society of Japan, 24 Sep. 2019 - Feasibility of Hydroge-Containing Sulfur Hot Spring Water Produced by UV Light Irradiation
H. Niihara; A. Tsuneshige; S. Okouchi
Journal of Hot Spring Science, Japan, 68, 2-12, 2018 - Isothermal Titration Calorimetry and oxygen Biinding Studies Between Inositol Hexakisphosphate and Human Hemoglobin
A. Tsuneshige; T. Yonetani
2018 - Isothermal Titration Calorimetry and Oxygen Binding Studies between Inosito Hexakisphosphate and Human Hemoglobin
A. Tsuneshige; S. Unzai; T. Yonetani, Biophysical Society Annual Meeting, February 17-21, 2018, Baltimore, Maryland, USA
2018 - Change of the isoelectric point of hemoglobin at the air/water infterface probed by the orientational flip-flop of water molecules
S. Devineau; K.I. Inoue; R. Kusaka; S.H. Urashima; S. Nihonyanagi; D. Bagi; A. Tsuneshige; T. Tahara, Phys Chem Chem Phys 19 (16) 10292-10300
Phys Chem Chem Phus, 2017 - 光反応による水素化温泉水の提案（V)
新原寛晃; 常重アントニオ; 大河内 正一, 日本温泉科学会第70回大会（2017）那須，栃木健
2017 - 水素水による紙の紫外線ダメージ御製効果（II)
常重アントニオ; 山岡 卓司; 新原 寛晃; 市田; 鍵和田 聡; 大河内 正一, 日本温泉科学会第70回大会（2017）那須，栃木健
日本温泉科学会, 2017 - Suppression Effect of Oxidative Damage on Hair by Hydrogen Water
2017 - Suppression Effect of Oxidative Damage of Hair by Hydrogen Water
H. Niihara, T; Yamaoka; K. Ichida; S. Kagiwada; A. Tsuneshige; S. Okouchi, The 7th Meeting of the Japanese Biochemical Society for Molecular Hydroge, Nagoya, Japan
2017 - Disassembly and Impact on Function of a Multimeric Allosteric Protein by Kosmotropes
A. Tsuneshige; S. Unzai, 日本生物物理学会 第55回年会，2017年9月19日-21日，熊本大学黒髪北地区，熊本市，熊本県
2017 - From Catenates and Rotaxanes to Molecular Switches, Sensors, and Cars
A. Tsuneshige, Acta Herediana, 59, 36-41
Acta Herediana, 2016 - Tracing Evolution of Whale Myoglobin by Resurrecting Ancient Proteins
Y. Isogai; H. Imamura; S. Nakae; K. Takahashi; T. Sumi; T. Nakagawa; A. Tsuneshige; T. Shirai, 54th Annual Meeting of the Biophysical Society of Japan, November, 25-27, Tsukuba, Japan
2016 - Characteristics of Acidic Sulfur Hot Spring Water
S. Okouchi; Y. Kurita; K. Umeda; A. Tsuneshige, J. Hot Spring Sci, 65, 2-13
Japanese Society of Hot Spring Sciences, 2015
- Alteration of an Obliterated Interface in a Classical Allosteric Protein Causes Unexpected Functional Changes
A. Tsuneshige
66th Biophysical Society Annual Meeting, 19 Feb. 2022 - Structural Insight into the Double Allosteric Mechanism for the Oxygenation Function in Hemoglobin: Beyond the MWC Model
A. Tsuneshige; S. Unzai
The XXth International Conference on Oxygen Binding and Sensing Proteins (O2PiP), 2018, [Invited] - Method for Introducing Hydrogen in Bathtub Water
H. Ohnami; A. Tsuneshige; S. Okouchi
The 8th Annual Meeting of the Japanese Society for Medical and Biological Research on Molecular Hydrogen, 2018 - Tracing Seal Myoglobin Evolution by Resurrecting Ancient Proteins
磯貝 泰弘; 今村 比呂志; 中江 摂; 墨 智成; 高橋 健一; 中川 太郎; 常重アントニオ; 白井 剛
第19日本蛋白質学会年会・第71回日本細胞生物学大会合同次大会, 2018 - 海洋哺乳類ミオグロビンの分子進化：自然はどのようにして高溶解度で安定な蛋白質を作り出したか？
磯貝 泰弘; 今村 比呂志; 中江 摂; 墨 智成; 高橋 健一; 中川 太郎; 常重アントニオ; 白井 剛
第5回富山・バーゼル医薬研究開発シンポジウム, 2018 - Isothermal Titration Calorimetry and Oxygen Binding Studies between Inositol Hexakisphosphate and Human Hemoglobin
A. Tsuneshige; T. Yonetani
The 62th Annual Meeting of the Biophysical Society, San Francisco, USA, 2018 - 光反応による水素化温泉水の提案（V）
新原 寛晃; 常重アントニオ; 大河内 正一
日本温泉科学会第70回大会（2017）9月6日～9日，那須, 2017 - 水素水による髪の紫外線ダメージ抑制効果（III）
常重アントニオ; 山岡卓司; 新原 寛晃; 市田 叶美; 鍵和田 聡; 大河内 正一
日本温泉科学会第70回大会（2017）9月6日～9日，名古屋，愛知県．, 2017 - Suppression Effect of Oxidative Damage of Hair by Hydrogen Water
Niihara, H; Yamaoka, T; Ichida, K; Kagiwada, S; Tsuneshige, A; Okouchi, S
The 7th Meeting of the Japanese Biochemical Society for Molecular Hydrogen, Nagoya, Japan., 2017 - Interactions Between as Classical Protein and a Strong Effector – Revisited
Sakurai; S.; Sawada; D.; Yonetani; T.; Tsuneshige; A.
60th Annual Meeting of the Biophysical Society February 27~March 3, San Francisco, USA., 2016 - Reconstruction of an Allosteric Protein from Its Components and the Origin of Allosteric Cross-Talk
Tokoro, T; Tsuneshige, A
XIX International Conference in Oxygen Binding, September 12-14, 2016, Hamburg, Germany., 2016 - Effect of chemical modifications of amino acids as point mutations in protein function
Tsuneshige; A.; Sakurai; S.
The International Cheical Congress of Pacific Basin Societies, Honolulu, HI. USA, 15 Dec. 2015 - 酵素による重曹泉の炭酸化について
常重アントニオ; 桜井 俊輔; 澤田 大貴; 中橋 里奈; 服部 佑亮; 大河内 正一
日本温泉科学会第68回大会，山形県天童温泉, 09 Sep. 2015 - Antialgae activity of calcinated colemanite
Hikari; S; Sato; A. Ohnami; H. Tsuneshige; A.; Okouchi; S.
The International Chemical Congress of Pacific Basin Societies, Honolulu, HI, UA, 2015 - Effects of magnesium hydride as a reductive bath additive for the skin
Kurita; Y.; Mukae; Y.; Umeda; K. Tsuneshige; A.; Okouchi; S.
The International Chemical Congress of the Pacific Basin Societies, Honolulu, HI, USA, 2015 - Sulfur hot spring containing hydrogen generated by UV irradiation
Niihara; H.; Mukae; Y.; Kurita; Y.; Umeda; K.; Tsuneshige; A.; Okouchi; S.
The International Chemical Congress of the Pacific Basin Societies, Honolulu, HI, USA, 2015 - Effect of hydrogen on plant growth subjected to salinity stress
Yamaoka.nT.; Kurita; Y.; Okouchi; S.; Tsuneshigem A.
The International Chemical Congress of the Pacific Basin Societies, Honolulu, HI, USA, 2015 - Evaluation of freshness of fermented foods by aging index criterion
Hattori; Y.; Kuria; Y.; Suzuki; T.; Okouchi; S.; Tsuneshige; A.
The International Chemical Congress of the Pacific Basin Societies, Honolulu, HI, USA, 2015 - Interactions between inositol hexakisphosphate and hemoglobin studied by isothermal titration calorimetry and oxygen binding measurements
Sakurai; S.; Sawada; T.; Yonetani; T.; Tsuneshige; A.
The 53rd Annual Meeting of the Biophysical Society of Japan, Kanazawa, Japan, 2015 - Insight Into the Origin of Allostery. Stepwise Reconstruction Of An Allosteric Protei n From Its Subunits
Tatsunori Tokoro
2014 IUPAB Congress, Brisbane, Australia, 03 Aug. 2014
■ Affiliated academic society
